Ryutaro Asada is enjoying his peaceful life in the countryside, when he is visited by Akira Kato, assistant professor of the Faculty of Cardiac Surgery at Meishin University Medical Hospital.

Ryutaro is a genius surgeon who used to lead "Team Medical Dragon," a world-class NGO medical team. In harsh environments that lacked medicine and electricity, Ryutaro witnessed many lives pass away. At the same time, he saved many other lives, helping his matchless skill overwhelm other doctors.

As a female doctor, Akira managed to become an assistant professor. She has ambitions to be promoted to professor by succeeding in a surgery using the Batista technique — an extremely difficult type of heart surgery — and also by writing a paper on it. A year ago, Akira witnessed Ryutaro's skills when he was an NGO doctor. That's why she recruits him and asks him to use the Batista technique. Since Ryutaro's arrival, urgent patients who would have been abandoned in the past, are miraculously saved by the "hands of God."

But Ryutaro's actions cause a stir in the closed university hospital, where power struggles happen everyday and the priority of doctors is to protect themselves. This environment doesn't stop Ryutaro from following his beliefs. Ryutaro's existence also bothers Dr. Noguchi, professer of the Faculty of Cardiac Surgery, the power broker of the hospital.

There is a man keeping a very watchful eye on Akira and Ryutaro's Batista team. It's Gunji Kirishima, Akira's boyfriend and assistant professor at a rival hospital. He and Akira have promised each other to carry on Japan's cardiosurgery. Gunji has also confronted Ryutaro in the past.

Other characters include Miki Satohara, an extremely brilliant nurse who looks up to Ryutaro and has more medical knowledge than the average doctor; Noboru Ijuin, an intern that first opposes Ryutaro, but is gradually influenced by him; and Professor Kito, who is looking for the opportunity to recruit Ryutaro away to the Emergency Room (ER).